Exact(7)
We also have an azimuth variant point target T3, the maximum backscattering envelope of which stays lower than both T1 and T2 (see Fig. 11 a).
Resolution recovery (RC) is possible by measuring a standard point source throughout the FOV and deconvolving the image signal with the spatially variant point spread function.
Spatial resolution can be recovered particularly in these regions by measuring a point source at given locations of the FOV and by incorporating a spatially variant point spread function (PSF) model into the iterative reconstruction process [39].
This calls for more accurate statistical modeling of distortions and noise coming from real capture devices (Poisson noise, internal non-linearities, space variant point spread functions due to nonideal optics, chromatic aberrations, etc).
A recent study that focused on the impact of PVE correction on tumor heterogeneity suggests in this case the use of local image deconvolution approach with expectation maximization and spatially variant point spread function (e.g., [ 52]).
These authors showed that the spatial resolution at the centre of the FOV could be improved from 6.5 mm with standard ordered subsets expectation maximization to 3.9 mm with an iterative reconstruction method incorporating the spatially variant point spread function (PSF) of the scanner.
Similar(53)
In line with this, several studies have reported an attenuated insulin response to oral glucose in individuals with the TCF7L2 risk variant, pointing to the possibility of a defective incretin system [ 7, 8].
Some of the variants point towards involvement of biological reasonable mechanisms while the role of others remains unclear.
Identified gene variants point towards various molecular pathways, e.g. neuronal dysfunction, vascular integrity and function, and pain signaling.
Overall, this generated 300 million human sequence variants (point mutants).
While the mechanism cannot be definitively assessed, the A92P and A89C/I94C LexA variants point to the importance of secondary structure formation in the cleavage region, with potential implications for inhibitor design.
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