Sentence examples for variant of interest from inspiring English sources
Due to the low frequency of the genetic variant of interest (<1% AA homozygous in individuals of Western European descent), which might be based on a negative evolutionary selection of the A allele to preserve an adequate Th17 response against infection, we only had access to individuals that were heterozygous for the IL23R R381Q gene variant.
In our problem, X i is a three-dimensional vector ( x i1, x i2, x i3) where x i1 is the SIFT score, x i2 is the PolyPhen score and x i3 is the PANTHER subPSEC score of the variant of interest, and Y i indicates the variant is positive (damaging CV) or negative (neutral CV).
These filters are ad hoc criteria that sometimes filter out the true variant of interest.
To conduct this assay, cells were first transduced with the tet-responsive vector carrying the MyoD variant of interest and selected in puromycin to obtain a pure population.
This showed that a key LPHN3 variant of interest is expressed in brain regions related to attention and activity including the amygdala, caudate nucleus, cerebellum, and cerebral cortex.
In the model, μ is the intercept; x is the n by 1 vector of genotypes for the variant of interest; and β is the variant's effect size.
No single BPS tool offers sufficient capabilities and the flexibility to resolve all the possible design variants of interest.
Among the genetic variants of interest are G894T endothelial nitric oxide synthase and G1958A methylenetetrahydrofolate dehydrogenase 1 gene polymorphisms.
Thus far, Krasnow and his colleagues have identified some 20 genetic variants of interest, including individuals with obesity, high cholesterol, cardiac arrhythmias, high blood sugar and unusual eye color.
Next-generation DNA sequencing makes it possible to rapidly compare the genetic content among samples and identify germline and somatic variants of interest, such as single nucleotide polymorphisms (SNPs), insertions and deletions (indels), copy number variants (CNVs), and other structural variations.
The study design depends on the effect size of the variants of interest.
