Sentence examples for variant of a population from inspiring English sources

Indeed, more than 2.9 million case control pairs should be recruited to a GWAS to identify a susceptibility variant of a population frequency between 0.0005 and 0.9995 with a power of 0.8 (Appendix C).

If the mutation rate at a putative risk locus is relatively low μ = 1.48 × 10 − 6, more than 290 million case control pairs are required in a GWAS to detect a risk variant of a population frequency between 0.000005 and 0.999995 with a power of 0.8 (Appendix C).

The observed complementary nature of applied multiple methods in identifying multiplicity of HIV transmission suggests the necessity of further development of alternative methodologies and bioinformatic techniques to improve the reliability of diagnostic and monitoring of the number of transmitted viral variants on a population level in the HIV/AIDS epidemic.

Recombination can allow variants of a population to escape from the current fitness peak (escape from Muller's ratchet) and re-appear with a new phenotypic make-up and/or even re-establish in a new host-relationship [ 7, 8].

Under variants of JG, a population of discriminators is invaded by unconditional defectors [ 17, 19] (but see Ref. [ 13]), or discriminators and unconditional cooperators are frequent in an island model if dispersal of offspring is confined within each island [ 10].

This is a consequence of one of the most important findings of classical population genetics the fate of a variant in a population is the product of N e and the strength of selection (Fisher 1930; Kimura 1962).

Because the estimates are not based on a probability sample and multiple measures are not considered as random variants of a single population measure, limiting the uncertainty to the amount of variation in the empirical data is a challenge.

Although, as outlined above, the techniques developed in this manuscript are quite general, we focus here on two important aspects of its application: detection and genotyping of variant alleles in a population of cells and comparing allele frequencies across different samples.

Interpretation of association studies is complicated by the number of genes, the number of variants in each gene, and the frequency of a variant within a population.

Relative proportions of the other four key concepts were similar between written and oral responses, and in order of relative frequencies were heritability, change in the frequency of a variant in a population, competition, and hyper-fecundity.

We cannot exclude phenotypic differences between those with and without the variant in a population of less affected individuals.