Sentence examples for variant is very from inspiring English sources

This variant is very rare in the general population (MAF = 0.1% in all 1000 Genome Project phase 3 individuals, 0.2% in 60,706 individuals of the Exome Aggregation Consortium ExAC), and has a possible damaging effect based on bioinformatic tools; the CADD PHRED-scaled C score is > 20, thus ranking in the top 1% of predicted deleteriousness of all possible single nucleotide variants [23].

The Fiji parrotfinch resembles the closely related royal and red-headed parrotfinches, and the rare blue-headed variant is very like the blue-faced parrotfinch, but these three species do not occur in Fiji.

Another important point from the present calculations is that the penetrance mode of the causative variant is very difficult to deduce from the apparent penetrance mode of the marker locus.

Since the minor allele for this variant is very rare (MAF = 0.008) in CEPH samples, we have very limited power to confirm or refute this association using the case-control population in the current study.

Twin and adoption studies have demonstrated conclusively that body weight is under genetic influence [1] [2] [3]; yet genomewide association studies reveal that the phenotypic variance associated with any one genetic variant is very small [4].

The overall architecture of the G93A variant is very similar to that of WT SOD1, particularly in the loop region of 90 93.

Our data confirm that an animal/nuclearid-like histone H3.3 variant was very likely ancestral to H3 variants of all opisthokonts.

A/H3N2 viruses, belonging to A/Perth/16/2009 antigenic variant, were very rarely detected, as well as influenza B strains, which co-circulated, but at a very low level.

We conclude that the neurodegenerative disease of the Chinese Crested rescue dog was neuronal ceroid lipofuscinosis and that homozygosity for the MFSD8 c.843delT sequence variant was very likely to be the molecular-genetic cause of the disease.

It is notable that the kcat and Km values for this variant were very similar to those of R141E/A306F, yet SEC data suggested that the E107R/D114R variant remained a tetramer.

Only when the OR of the rare variant was very large, its frequency higher and disease risk high, were the AUC and NRI >0.01) improved across a wider range of baseline AUC.