Suggestions(1)
Exact(7)
Further analysis of the p.R150Q amino acid variant is needed to assess what role, if any, it might have in hearing loss.
Further analysis of the p.I663V amino acid variant is needed to assess what impact, if any, this variant might have on prestin production, trafficking and/or function.
Further investigation of the p.I67V amino acid variant is needed to assess what impact, if any, it might have on prestin production, trafficking and/or function.
Functional evaluation of this variant is needed to fully understand the relationship between inherited PIK3CA variation and breast cancer risk.
The pathogenicity of Pro143Ala variant is needed to be confirmed by further large-scale replication studies involving more patients and controls in Asian populations.
At the same position, the one-mutation model log10(Bayes factor) is much smaller at 5.23, which strongly suggests that more than one variant is needed to explain the association.
Similar(53)
However, further delineation of the diagnosis-associated susceptibility variants is needed to better characterize the genetic architecture given the disease's complex nature.
Some dose of cooperation among viral variants is needed.
Tailored modeling and testing of X-linked variants is needed to properly incorporate X-inactivation.
Therefore, we urge that disease- or application-specific treatment of genetic variants is needed, beyond simple variant annotation.
Therefore, in order to get a 'typical' quasispecies profile both competition and cooperation or facilitation between viral variants is needed.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com