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The protein has been sub-classified into three variant groups.
It has been classified into three main non-cross-protective variant groups.
We report a murine IgG1 mAb, JAR 41, which broadly cross-reacted with fHbp sequence variants from all variant groups.
The mAb bound to the surface of live meningococci with fHbp from each of the three variant groups.
Based on sequence variability of the entire protein, fHbp has been divided into three variant groups or two sub-families.
(a) Three major variant groups related to the reference minor allele (RMA) correction (false-negative, false-positive RMAs, variant-type misannotations), as implemented in the RMA Hunter tool.
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However, the high-risk variant group also showed the best chance of recovery.
Most anti-fHbp antibodies are variant group-specific and recognize epitopes on the C-terminal domain.
Similarly, values for all dynamic parameters were greater in the variant group.
G1 is considered the most important Stx2 variant group in terms of human pathogenicity.
Consequently, one 7M variant (plate) evolves into one NM plate consisting of two twin-related fine variants, and four differently oriented 7M variants in one variant group result in a total of eight NM variants.
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