Sentence examples for variant groupings from inspiring English sources

However, the more rare variant groupings and tests considered, the less efficient and more computationally intensive the approach will be compared to that which most accurately tests the true underlying model.

A unique feature of RAREMETAL is the ability to customize variant groupings for gene-level statistics at the meta-analysis stage, after individual studies are analyzed.

The basic idea behind most rare variant association tests is to group variants likely to have an impact on the function of a specific gene and to compare the distribution of these variant groupings to the distribution of the trait of interest.

Additional types of ECM, which gave the best results, were selected for comparison, and also three variants of groupings of types, options 11 13 ECM (Table 1).

Additional groupings have been identified within genotypes which have been variously termed subtypes, clades, variants, groups, or strains and which for the sake of clarity are herein termed strains.

We also examined the detected genes, collapsing all splice variants, in functional groupings determined by Gene Ontology [ 24] annotations.

Such descriptors may be applied to describe functional, stage-specific or other groupings of variants that do not necessarily form phylogenetic clades.

However, such algorithms vary in the information used, and can give different results, which would lead to different groupings of rare variants.

To assess the association of genetic variation with sepsis outcomes we conducted three separate analyses of two groupings of detected variants.

The BF between and the null model is We define the final as a linear combination of submodels by choosing a weight for each grouping with the constraint The corresponding BF is Note that by giving a weight of 0.5 to each of the two groupings in which all variants belong to the same group, and a weight of 0 to all other groupings, we are back to the SEM.

Again, tests with alternative groupings are more powerful than that with grouping all variants.