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To investigate whether galactose-1-phosphate uridyl transferase (GALT) variant genotypes were associated with epithelial ovarian cancer risk, and to determine if this association was modified by lactose intake.
ETV6 variant genotypes were compared with non-ALL controls to define ALL-related germline risk variants.
Phenotype-genotype analysis also suggested that the XPC rs1870134 CG/CC variant genotypes were associated with significantly decreased expression levels of XPC mRNA in a mix population of different ethnicities.
Among these eight SNPs investigated, only XPC rs1870134 CG/CC variant genotypes were associated with a decreased risk of prostate cancer under a dominant genetic model (adjusted odds ratio [OR] = 0.77, 95% confidence interval [CI] = 0.64-1.91, P = 0.003).
We found that the -842C variant genotypes were associated with decreased risk for SCCHN [Odds Ratio (OR) = 0.74; 95% confidence interval (CI) = 0.59-0.93 for the CG genotype, OR = 0.82; 95% CI = 0.34-2.01 for the CC genotype and OR = 0.74; 95% CI = 0.59-0.93 for CG+CC genotypes, compared with the GG genotype].
RESULTS: It was found that, compared with -786TT, the -786C variant genotypes were associated with a significantly increased risk of breast cancer in an allele dose-dependent manner (adjusted odds ratio [OR], 1.33 [95% confidence interval (95% CI ], 0.99-1.77 for -786TC; and OR, 1.79 [95% CI, 1.11-2.87] for -786CC; P trend) =.007), but 27-bp VNTR and 894G>T genotypes were not.
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Variant genotypes are the dominant reason for variety of phenotypes.
Complete genomes or user-specified regions (e.g. chromosome) may be inputted and viewed, with variant genotypes being colour coded.
A major barrier to understanding the role of polymorphic DNA repair genes for environmental cancer is that the functions of variant genotypes are largely unknown.
The relevance of variant genotypes was further studied in a series of 462 colorectal cancer patients and 245 healthy controls [ 43].
Prevalence of the variant genotypes was 4.2% for APE1 glu/glu, 13.8% for hOGG1 cys/cys, and 27.8% for GSTM1 null.
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Justyna Jupowicz-Kozak
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