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The remaining 32 redundant probe set pairs were associated with only one knownGene mRNA; one possible explanation for this result is that there may be some additional variant forms that have not yet been discovered or not yet recorded in the knownGene collection (Data S7).
Several members of the BMP protein family are expressed in variant forms that are translocated to the nucleus rather than being secreted from the cell [ 20].
Of special note is the diffusion of interests from overtly political and strategic analyses of women in society and culture, to exploration of the variant forms that gender can assume, a shift that also distinguishes aspects of the transition from feminism to postfeminism.
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In silico analysis suggested a novel secondary protein structure and catalytic domain binding site in the variant form that was different from the native form which contained (AG 18 microsatellite repeats (see Additional file 10).
Bcl-x was hyperexpressed in the majority of SCLC and NSCLC cell lines as compared with normal tissues, and all lung tumour lines preferentially expressed bcl-x1-mRNA, the splice variant form that inhibits apoptosis.
ANXA11 rs1049550*T, located in the first conserved annexin domain, has been reported to be associated with a variant form that protects against sarcoidosis in European Caucasians (Gerke and Moss, 2002; Draeger et al, 2011).
Alternative splicing results in multiple transcript variants, including two forms that contain either 27 or 38 amino acids (PACAP27 and PACAP38).
This is strongly supported by the gene expression of prostanoid receptors, FP, and its splicing variants, notably the altFP4 variant that forms a bimatoprost-sensitive activation site with FP (FP/altFP4; refs. 20, 30), in scalp hair follicles and isolated dermal papillae and CTS in vivo.
"I tried to develop a vocabulary of forms that would be comprehensive enough for all the variants that exist," she notes.
Genetic variants of the IRF5 gene have been associated with susceptibility to SLE in multiple populations; in each population, a distinct group of IRF5 single nucleotide polymorphisms and genetic variants form haplotypes that confer risk for, or protection from, the development of SLE.
Notably, stalling was observed for a variant that formed a stable 10-stranded intermediate but not for one in which this intermediate was unstable.
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