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Dynamic majority and Consensus voters: Unlike the previously described voters, dynamic voters are not defeated when any variant fails to provide a result (Pullum [2001]).
This possibility is supported by the experimental data which show that this variant fails to block IL22 activity [ 31].
However, consistent with the role of the BRCT domain in mediating interactions with the end-joining factors, the variant fails to perform synthesis in the context of NHEJ.
The homodimeric coreBMP2L51P variant fails to induce ALP expression, which is in agreement with results published earlier using similar BMP variants that have both type I receptor sites destroyed [ 33, 40].
The anaerobic activity of the C122A FNR variant, which lacks one essential iron sulfur cluster co-ordinating cysteine residue, was close to that of the vector control, suggesting that this variant fails to acquire a [4Fe-4S] cluster in vivo.
Comparing the degree of rescue obtained with either human SHANK2-WT or the three variants, we can demonstrate that only the R462X variant fails to rescue the excessive branching to a normal level, an effect that fades out 75 µm away from the cell body (Fig. 3B and C).
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Indeed, in the current study, seven of the subjects with the mutant variant failed to respond to SSRIs, and the other two required extremely high doses.
Cell extract with N311A variant failed to show any detectable cleavage activity (data not shown).
In contrast, introduction of the K57A variant failed to provide any rescue.
They reported that when expressed in COS-7 cells, the variant failed to reveal any transport activity.
This confirms prior work showing that cells expressing the ATG16L1 T300A variant fail to clear intracellular pathogens.
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