It is tempting to propose that the balance of fibulin-1 variant expression is an important determinant of whether the expressed fibulin-1 displays tumour-suppressive or oncogenic activities.
However, transcription profiling of SVSP genes in both T. annulata and T. parva infected cell lines does not fit the classical pattern of variant expression, as the majority of SVSP genes are co-expressed at the RNA level [ 7, 20].
The prediction of our theoretical model that alternative splicing is favored by a strong tissue specificity in splicing variant expression fits well with the observation that PS genes are expressed in more tissues than MS genes (Figure 2B).
Therefore, m-spinesin variants may have distinct biological functions arising from organ-specific variant expression.
Instead, from whatever cause, CIN is directed towards solutions to environmental stresses when it arises, which would then account for the conditional variant expression of aneuploidy in cellular contexts.
Elevated growth hormone (GH) levels lead to increased circulating insulin-like growth factor-I (IGF-I), but the effects on localised muscle IGF-I splice variant expression is not known.
This suggests a possible interaction between the genetic variant, expression and the group phenotype.
These data suggest that as in mice, human splice variant expression varies between organs.
For this, we induced CPY* and variant expression in wild type cells.
It suggests that if splicing variant expression is free to evolve in different tissues, selection should promote tissue specific expression.
Embryonic stem cells are a heterogeneous cell population, consisting of subpopulations with variant expression levels of pluripotency-associated markers and differentiation status [41].
