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However, most CNVs are not common (Itsara et al., 2009), which leaves CNVs as a contender for rare-variant explanations of missing heritability.
A back-to-back comparison of the properties of the dissociable wild-type FRP dimer, its monomeric mutant form, and the disulfide-trapped dimeric variant permits an explanation of different stoichiometries (1 1, 1 2, and newly found 2 2) and topology of the otherwise kinetically unstable OCP FRP complexes.
The relevance of disease-related genetic variants for the explanation of social inequalities in complex diseases is unclear and empirical analyses are largely missing.
However, on the molecular level the relevance of disease-related genetic variants for the explanation of social inequalities in health is still unclear and theoretical approaches as well as empirical analyses incorporating genetic data are largely missing.
However, not all bacteria synthesize folate de novo but instead rely on an external supply [see Additional File 1, variant 001; see "Methods" for an explanation of the variant code].
Here we test the predictions of two evolutionary explanations of senescence mutation accumulation and antagonistic pleiotropy which postulate that genetic variants with harmful effects in old ages can be tolerated, or even favoured, by natural selection at early ages.
Puzzling explanations of military jobs.
Causal Explanations; Models; Explanations of Meaning; Narratives.
Adapting a variant of Yogi Berra's explanation of the difficulty reserving a table at his favorite restaurant -- "nobody goes there anymore; it's too crowded" -- many potential customers believe they get more personal attention when they take classes in residence than when they take them over the Internet.
The background of this assay variant is significantly lower, supporting our explanation of the high background in assay variants 1 and 2. Furthermore, the novel assay has fewer steps and requires less time.
These data suggest that the explanation of the variant course, at the genotype level, is hardly possible.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com