Sentence examples for variant exhibited increased from inspiring English sources

This variant exhibited increased degradation activity compared with the wild-type mouse enzyme (Supplementary material) and was suitable for chronic dosing in mice.

In our current work, two different approaches were used to identify reovirus variants exhibiting increased interferon sensitivity.

Phospho-deficient Smo variants exhibit reduced cell surface expression and diminished Hh signaling activity, whereas phospho-mimetic Smo variants exhibit increased cell surface levels and constitutive activity.

Figure 3(a) shows that all pulse selected MDA-MB-435S-F variants exhibit increased levels of Pgp (p-glycoprotein) and MRP-1 by Western blot.

Additionally, we observed statistically significant evidence that carriers of the SOD2 and SOD3 variants exhibit increased glioma dose response relationships compared with homozygous wild-type subjects (P-trend < 0.001).

Indeed, the variant V374I exhibited increased IL-6 secretion when expressed in MCF-7 cells compared with WT-374V.

Finally, NOD2/CARD15 was found to be involved in the regulation of TLR2 [ 18] and carriers of the variant alleles exhibited increased intestinal permeability [ 19].

Further, ZnT8 deficient mice and humans with the Trp325Arg ZnT8 variant exhibit increased insulin clearance.

In line with these clinical findings, animal study showed that a variant BDNF mouse (BDNF Met/Met) reproduced the phenotypic hallmarks of humans with this variant allele, and exhibited increased anxiety-related behaviors [ 19].

Although the deleterious class exhibited increased variants with deleterious effects, a more informative approach would be to examine a subset of variants with an even higher likelihood of being deleterious, e.g. nonsense mutations as suggested by Szpiech et al. [ 24], as these are more likely to interfere with normal protein functioning.

Larvae inoculated with small colony variant strains Aus0041, Aus0078 and Aus0087 exhibited increased survival rates.