Tumours from two carriers of the G1738R variant differed from each other in most respects, with only one displaying features characteristic of BRCA1 tumours.
Two genetic variants of the North American WNV strain were isolated in Texas in 2002; the major variant differed from the New York 1999 isolate by 0.18% of nucleotides, and the minor variant by 0.35% (1).
These results indicate that the PSG9 proteins expressed by placental cells and tumour cells have similar sequences and might have similar function, however, the level of expression of each PSG9 variant differed from those found in placenta.
Compared with GII.4/Sydney/2012, this variant of GII.17 displayed a high epidemic activity; in only 2 months, an increased number of related outbreaks were reported in 10 cities. Sequence comparison with archived GII.17 strains from GenBank suggests that the GII.17 genotype identified in Guangdong is a newly emerged variant, differing from GII.17 strains detected before 2011.
Assembly of the 5S rRNA gene confirmed three variants (data not shown); downstream of the 5S rRNA gene, all three variants differ from Methanoculleus marisnigri JR1, indicating a different genomic context for the rrn cluster.
These variants differ from one another by the presence of either C or T nucleotide at codons 112 and 158.
CenH3 variants differ from the other H3 variants by a long extension of the N-terminal tail, which are not conserved among eukaryotes [ 5, 6].
Variants differ from canonical histones in their protein-protein interactions, localization in chromatin, number and types of PTMs, nucleosome stability, and tissue-specific expression profiles [ 5].
Most of these variants differ from each other at the second (X) and/or fourth (Z) amino acid position in the cyclic heptapeptide.
However, it has not been addressed whether these variants differ from the standard genetic code as far as mutation and translation loads are concerned.
