Sentence examples for variant demonstrated that from inspiring English sources

Performing the same experiment with the H103Y variant demonstrated that the mutation significantly decelerated the two-electron transfer reaction from glucose to the redox cofactor (Fig. 4).

Rescue of cpx-1 mutants with the GG variant demonstrated that insertion of a GG between the AH and CH was equivalent to deleting the entire AH domain.

Overall, the structure of the V266H variant demonstrated that the inhibition could not be explained by disruption of the short-range allosteric network because the His His266′ side chains were accommodated in the interface, albeit with repositioning of neighbouring tyrosine side chains.

In that study, transcriptional analysis of htrA levels in opacity variants demonstrated that transparent strains produce more htrA transcript than the opaque variant during late-exponential phase.

Inhibition of PfFPPS/GGPPS by MMV019313, but not bisphosphonates, was disrupted in an S228T variant, demonstrating that MMV019313 and bisphosphonates have distinct modes of inhibition.

The results obtained with this variant demonstrate that it is possible to display a peptide in the OmpA β-barrel without negative effects on protein levels or OM insertion.

Our functional analysis of a human disease-associated gene variant demonstrates that IL23R R381Q exerts its protective effects through selective attenuation of IL-23-induced Th17 cell effector function without interfering with Th17 differentiation, and highlights its importance in the protection against IL-23-induced tissue pathologies.

In addition, the data from the WYA+2 variant demonstrates that Arg-182 is not essential for EnvZ function, suggesting that maintenance of change density in this region is not critical.

The results of our in vivo studies with orthotopic xenograft models of the metastatic MDA-MB-231 variant demonstrate that ectopic miR-18a expression significantly attenuated continuous expansion of primary tumor mass and decreased spontaneous lung metastasis.

The re-creation of a human disease-causing TNNT2 splice variant demonstrates that sarcomeric mutations can alter cardiomyocyte biology at the earliest stages of heart development with distinct effects from those observed in adult hearts despite shared transcriptional responses.

The 1.63 Å (1 Å = 0.1 nm) structure of the variant demonstrates that the mutation is accommodated at the dimer interface to generate an enzyme with substantially the same activity and specificity as wild-type caspase-3.