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Exact(6)
The larger the difference between entropies, the more conserved (longer) the haplotype that carries the minor variant, consistent with a recent selective sweep.
Evaluation of encapsulation by buoyant density centrifugation showed high density for the HH variant (consistent with low encapsulation [LC]) and low density for the LH strain (consistent with high encapsulation [HC]).
This digestion product was detected at high abundance with the modified counterpart present at <15% of the unmodified variant, consistent with hypomodification of 4-thiouridine at position 8 within this tRNA.
Mutations at P14P12 and P4, but not P10P8 or P2P1′, resulted in a decrease in detectable polymer in a cell model that recapitulates the intracellular polymerization of the Z variant, consistent with polymerization from a near-native conformation.
Amplification of the AChE-R splice variant required at least five cycles more than were necessary for detection of the AChE-S variant, consistent with its much lower abundance, even under conditions that increase expression (Perrier et al. 2005).
However, subsequent re-probing of the same membrane using the rat anti-EGFR (ICR10) antibody, which is directed against the extracellular domain of the EGFR, revealed a marked increase in the level of EGFR in DiFi62 cells compared to the level of EGFR in DiFi parental cells and in DiFiG resistant variant, consistent with the findings of the flow cytometry.
Similar(54)
Although many SNPs represented very rare variants, consistent with previous findings of an excess of rare variants in Africa21, 135,708 (37.1%) were non-singletons, and 35,228 (9.6%) had minor allele frequencies of greater than 1% in the overall dataset.
Together, these results suggest a crucial role of W32 in maintaining the structure and stability of SOD1 in the context of both WT and G93A variants, consistent with our observation from the above TEM and DSF analysis.
Photobleaching analyses revealed a significant reduction in the mobilities of mHttex1 variants consistent with their incorporation into soluble microcomplexes.
In both cases allelic size variants, consistent with amplification of a single discrete locus, were detected.
There were no variants consistent with de novo mutation in both children (with presumed germline mosaicism in a parent).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com