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Both non-variant and LCS6 variant cells formed endometriosis-like lesions with both glandular and stromal components (Fig 5a).
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The untreated T9 cells formed subcutaneous tumors.
The untreated T9 cells formed tumors.
Gray-matter cells form projections called horns.
The phloem cells form a similar continuum.
Merkel cells form parts of sensory structures.
Line1 cells form subcutaneous (s.c).
H69/41d cells have a distinct morphology: while H69 cells are non-adherent cells that form ragged aggregates, the variant cells, while also non-adherent, form tight spheres reminiscent of those seen with stem cell populations (Figure 5A).
The behaviour of the variant cells in this model resembled those in mice with an activated KRAS gene that form endometriosis de novo (Dinulescu et al, 2005).
They manipulate adjacent cells to form cell-cell adhesions (known also as viral synapses) to spread from cell-to-cell.
It was proposed that cancer stem cells resemble bacterial persister cells in 2007 (http://forms.asm.org/microbe/index.asp bid551533), based on the common pathways between bacterial persisters, biofilm and L-form bacteria (cell wall-defective variants formed under cell membrane stress) and cancer stem cells.
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