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In contrast, mean t0.5cat was reduced to 2.87 days for the D494N variant and to less than 0.071 days for all mini-proteins.
These functional amino acid changes lead to a higher dopamine-degrading activity (H: high) for the Val158 variant and to a lower thermostability and enzymatic activity (L: lower) for the Met158 variant [6-8].
Based on the proposed extension, we outline our research roadmap to consider these constraints in an online shop of an e-commerce system, in which a potential customer shall be able to configure a product variant and to virtually layout it according to the assembly constraints.
Further experiments are needed to identify additional cell lines, beyond ACHN, that express the HAVCR1a variant and to assess the sensitivities of such cell lines to ε-toxin.
Indeed, many carcinomas might present a clear cell variant and to date, there is no specific marker to differentiate metastatic clear cell carcinoma of one site from another.
An association between DNMT3L and intelligence would be consistent with the critical role of DNMT3L in imprinting and the evidence linking imprinting to cognitive function but more work is needed to determine which function of DNMT3L is influenced by the 11330C>T variant and to investigate how this process might influence human intelligence.
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The contributions of rare genetic variants to metabolome variance and to the human phenotype have been underestimated until now.
He wanted to see humanity in its many variants and to do so in his own, almost anachronistic way — face to face, over time, away from our burgeoning apparatus of computers and algorithms.
However, someone with an unusual degree of genetic protection from cancer is unlikely to present in the same way, making it harder to identify the relevant gene variants and to extrapolate from this knowledge to find a way to help prevent cancer in others.
Related to the selection of variant services, we have considered two main issues, to select diverse variants and to determine an appropriate degree and/or selection of variant services.
Functional studies are done to confirm the pathogenicity of identified variants and to investigate underlying disease mechanisms, including studies on patient fibroblasts and zebrafish.
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