Sentence examples for variant alleles we from inspiring English sources

To determine whether there was a linear trend with increasing variant alleles, we calculated P values from Wald statistics including an ordinal variable for genotype.

To evaluate, whether chromosomal imbalances (especially loss of heterozygosity; LOH) might have contributed to the selective loss of the variant alleles we performed copy number (CN) and genotype analysis using Affymetrix 6.0CNV/SNP Arrays (Additional file 1: Table S4).

To determine if there was a linear trend with increasing variant alleles, we calculated p values from Wald statistics including an ordinal variable for genotype regressed on square root transformed percentage mammographic density.

In the multivariable regression models that included an interaction term between baseline bone lead levels and an indicator for having any HFE variant alleles, we found a significantly positive interaction for PP.

Interestingly, we found that when simply including common variant alleles (no available genotypes), we detected imbalances with similar sensitivity (>73 %) and precision (>75 %) as with partial genotype information (Table  2).

Although some researchers have identified incomplete repair of DNA damage or of aromatic DNA adducts in the presence of ERCC2 variant alleles [ 42, 54- 58], we hypothesize that the malignant entity of the C (Glu) allele of ERCC2 Lys751Gln is responsible for poor prognosis of early relapse among CRC patients receiving similar chemotherapeutic regimens in this study.

The haplotype comprising of the T allele of CYP19utr3' SNP1, the variant number of repeats of CYP11 and the variant alleles of CYP1A1m1 and m2 we associated with high E2 levels (above median).

The genotypes of ABCG2 34G > A, 376G > A, and 421C > A were homozygous for the wild-type, wild-type, and variant alleles, respectively (Table  1).> We here report a patient with metastatic RCC who developed severe sunitinib-induced toxicities, including hypertension, high fever, liver dysfunction, and thrombocytopenia, after only 10 days administration of sunitinib.

In the U.S. analysis of seven SLC23A2 SNPs, we found that variant alleles for rs6133175 and rs1715364 increased SLL/CLL risk and rs1776948 for FL and SLL/CLL.

Why do we find rare variant alleles like N opa23 if they are deleterious in many backgrounds?

We observed that variant alleles of rs2292779 and rs11786030 in AGO2 were commonly associated with poor DFS and poor OS.