This histological variant accounts for 5%15%% of all chordomas and up to 33% of all cranial chordomas, being preferentially found on the spheno-occipital side of the skull base [ 3].
KRAS mutations occur most frequently in 30 40% of all colorectal cancers [11] and BRAF mutations are present at a frequency of 5 22%, in which the constitutively activated BRAFV600E variant accounts for ∼90% of all the BRAF mutations [12].
One important question is whether the nonsynonymous variant accounts for all of the association signal at IL23R.
The most common variant is a recombination between exon 1 of TMPRSS2 and exon 4 of ERG, designated T1/E4 (Clark et al, 2007; Jhavar et al, 2008), and some studies indicate that this variant accounts for 85% of reported fusions (Wang et al, 2006; Mehra et al, 2007).
The highest absolute expression level of ACC2.v2 is observed in adipose tissue, where the splice variant accounts for over 20% of ACC2 expression, at levels comparable to ACC1 expression.
The mixed variant accounts for only 1% of cases.
In contrast, the plasma cell variant accounts for 9% of cases and tends to be clinically aggressive.
The predominant S-30S-18 S-30S-18 S-30S-18for 54% of the alleles examined; the remaining variants constitute 17% (S-30P-18), 11% (L-30S-18), accounts(L-30P-18) oforhe total Figure 2B.
Indeed, genome-wide association study (GWAS) have revealed hundreds of variants that contribute to the variability of height but could explain only a limited part of it, and no single variant accounts for more than 0.3% of height variance.
The H2A.X histone variant accounts for up to 10% of total histone H2A [87] and the presence of the C-terminal SQEY motif, containing S139, distinguishes it from its canonical counterpart.
