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Thus, reducing the dimensionality of Cell Death and Mitosis sets using a principal component analysis that captured ∼80% of the variance raised the number of significant correlations to 12 and 14 sets, respectively (Fig. 4B, right); these numbers corresponded to a total of ∼60% of the signatures examined, irrespective of their type or condition.
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Importantly for the co-variance argument raised above, IL-4 also increases the expression of CB1 receptors in lymphocytes [27], [28] so we elected to focus on that molecule as a "test of concept" that a component of the tumour microenvironment can influence FAAH activity.
In these patient surveys, high item scores combined with low variance [ 3] raised questions about the usability of patient experiences to measure differences in quality and of using the patient's perspective as an instrument to improve the quality of care.
The characteristics of the participating children/young people and parents in our study may explain some variance in the issues raised.
A second shortcoming was that all questionnaires were completed by children themselves, thereby introducing a shared variance problem which raises questions about the validity of the observed findings.
Autism status, when entered into the model, raised the explained variance to 1.91%.
Moral norm added in step 3 raised the explained variance by 2.3% (R2 change = 0.023 p < 0.001).
Entering number of types of OML in step 2 raised the explainable variance by 1%% (Nagelkerke R = 0.21).
Entering HIV information exposure, HIV/AIDS experience, attitude toward people with HIV/AIDS and perceived risk of HIV/AIDS in a second step raised the explained variance to 11% (R 0.11).
Entering need related variables in step III in terms of DMFT status, perceived oral health and general health raised the explained variance to a final 16.8% (Nagelkerke's R square 0.168, p < 0.01) (Table 5).
Entering enabling factors in step II in terms of knowledge on HIV transmission, personal experience with HIV/AIDS infected people, perceived risk of contagion in dentistry and attitudes towards HIV infected people raised the explained variance to 10.4% (Nagelkerke's R squared 0.104, p < 0.000).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com