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Taken together, the effect of genetic variance of proteins involved in the process of renal sodium reabsorption, such as NEDD4L, is likely to be much greater on the phenotype of salt sensitivity than on population blood pressure.
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Thus, in the expression [Eq (16)] for the variance of protein copy number, cooperativity has no effect on the switching noise but actually increases the diffusion noise by a factor of h2.
If the dominant noise source is a single step in transcription, then the number of mRNA transcripts will obey the Poisson distribution, and the variance of protein copy numbers still will be proportional to the mean, but the proportionality constant will be enhanced by the burst size.
Accordingly, across all protein interaction datasets, ePPID explains a higher percentage variance of protein evolutionary rate than PPID.
To address this question, we studied the percentage variance of protein evolutionary rate explained by ePPID when protein abundance is controlled for (the last column of Table 2).
Then, we studied the percentage variance of protein evolutionary rate explained by PPID when protein abundance is controlled for (column 4 of Table 2).
The method for computing the percentage variance of protein evolutionary rate explained by ePPID when protein abundance is controlled for was as follows.
Results show that the first principal component explains much more variance of protein evolutionary rate than the other components in all the six datasets.
However, the variance of protein evolutionary rate explained by ePPID is still the lowest in the "Y2H-union" dataset, which may be explained in three ways.
Similarly, although the shape of the distribution in variance of protein expression differed between human and chimpanzee ACC, CN exhibited a similar shape of distribution of variance between the two species.
Since ePPID explains the variance of protein evolutionary rate over three times higher than does the number of binding interfaces, we conclude that ePPID predicts protein evolutionary rate better than the number of binding interfaces.
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