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Because it is insensitive to noise and variance of parameters, it is very suitable for time-varying network systems.
In order to express a lower bound on the variance of parameters, the CRB [18] is given, which is used as the theoretical bound to evaluate the performance of practical estimation methods in many papers [19, 20].
Solar extreme ultraviolet (EUV) irradiance is the main ionization source of the F2 region of the Earth's ionosphere (Tobiska 1996; Chen et al. 2012), explaining around 90% of the variance of parameters such as the critical frequency of the F2 region (foF2) and the peak height of electron concentration (hmF2).
The t-values were calculated as follows:
In the context of Pop-PBPK models, refinement focuses on distribution type and variance of parameters.
Although the use of NLMEM has been shown to provide very precise and accurate estimates of the parameters even in presence of sparse designs, it should be acknowledged that these estimates are done on the population parameters, i.e., the mean and the variance of parameters in the population.
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Sensitivity of the new filter to the size of parameter uncertainty, in terms of the variance of parameter perturbations, is also considered.
The Cramer Rao lower bound is compared to the variance of parameter estimates for simulated data using a least-squares estimation procedure.
The variance of parameter θ m is given by the m th diagonal entry of the asymptotic covariance matrix: C asymp = I - 1 = σ 2 2 Re J H J - 1. (16).
We used 90% highest probability marginal-density (HPD) to examine the variance of parameter estimates.
Setting stricter values (lower δ and higher ζ) will result in lower variance of parameter estimates.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.
Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com