Thus, to the best of our understanding, these theories cannot account for the current findings, and do not shed light on why the dmPFC does not encode the behavioral cost of high variance arrays.
These gene-specific ERs and their variance (gene CV) were used to calculate array-based variances (array CV), which, in turn, were used to study the effects of array age, probe cDNA quantity and quality, and quality of spotted PCR products as estimates of technical variation.
Decomposition of principal components of variance of array signals and read frequencies, FDR corrected analysis of variance (with inclusion of the non-diagnosis components of variance discussed above as fixed effects) and chi squared comparisons of GO annotations were also performed with JMP Genomics, Version 3.2.
Pooling variance and array variance are both estimated by calculating allele frequency differences across two paired (by SNP, for all SNPs on the array) arrays [ 17].
Our purpose is to calculate empirical estimates of pooling variance and array variance, and then to estimate pool construction variance by subtraction.
While Wang utilizes the SF to measure the robustness of high-order superdirectivity, since it is directly related to the sum of the variances of array errors and it could provide more information than eigenvalue [12].
For each normalization method, filtering was based on gene variance across arrays.
The probe hybridization intensity signal was quantile normalized [26] across all probes to further correct for systematic variance in arrays.
Non-specific filtering was used to remove genes with low variance between arrays using a cutoff of 0.25.
The means for different composite diplotypes and residual variance are arrayed by a quantitative genetic parameter vector Θq = (μ2, μ1, μ0, σ2).
