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Proper formulation of that metal ion's coordination sphere sets the stage for construction of appropriately configured Schiff ligands based on tromethamine and variably modified vanillin core components.
In the ER, the PrP polypeptide undergoes oxidative folding with formation of a single disulphide bond, and the protein is variably modified at two N-glycosylation sites, resulting in a mixture of di-, mono- and unglycosylated forms [6].
The genetic architecture and biochemistry of these variably modified ß-branching events have been reported for several natural products, including curacin A (AY652953) [4], jamaicamide A (AY522504) [2], mupirocin (AF318063) [35], bacillaene (U11039) [37], [37], pederin (AY059471) [38], and myxovirescin (NC_000964) [39].
They have a glycosylated lipopeptide core that is variably modified by O-methylation and O-acetylation (Fig. 1).
Specific sets of variably modified disaccharides, usually within the sulfated domains, define binding sites for a multitude of specific ligands such as cytokines, chemokines, growth factors, enzymes and enzyme inhibitors, and ECM proteins [ 14, 15].
Ovocleidin-116, expressed in uterine cells and found to be most abundant during the rapid growth phase of mineralization, is the core protein of ovoglycan, a variably modified dermatan sulfate proteoglycan detected in SDS-PAGE at 120 and 220 kDa [ 6, 62].
Similar(54)
Mass spectrometric analyses showed that Aβ deposits contained variably truncated and modified wild type and mutated Aβ species.
Mass spectrometric analyses on temporal cortex samples showed that the Aβ deposits contained variably truncated and modified wt and mutated ArcAβ species.
Our mass spectrometric analyses, in which we immunoprecipitated both wt and mutated Aβ from the temporal cortex of the patient Sw2 with antibodies against two distinct Aβ epitopes (ArcAβ17 24 and wtAβ17 24), demonstrated that the deposits contained variably truncated and modified Aβ species, both wt and Arctic Aβ.
This is because macronucleus genes represent a modified, often variably amplified and rearranged subset of micronucleus genes [ 75, 76, 78].
A variety of additional characters in the highly modified forelimbs of plotopterids also variably support the monophyly of the Plotopteridae (since many of these elements are unknown in Phocavis and Plotopterum, their status as synapomorphies are partially dependant upon method of character optimization).
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