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Two of the three identified mutations affected known oncogenic hotspots of RAS genes and conferred variably enhanced RRAS function and stimulus-dependent MAPK activation.
We also observed that APR-246 variably enhanced the apoptosis-inducing capacity of the chemotherapeutic agent Etoposide, which is currently used in the treatment of patients with ES (data not shown).
To directly test in vivo the role of CC structures in the aggregation and dysfunction of RUNX2, we generated different mutant forms of polyA-expanded and non-expanded RUNX2 (Fig. 3A) with variably enhanced or reduced CC stability, as determined with Paircoil2 (Fig. 3B; Supplementary Material, Fig. S3A).
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Extraventricular neurocytoma has been described as well-demarcated mass, partly or mainly cystic (50%), variably enhancing, with or without edema.
Furthermore, MRI scans of children with monophasic ADEM typically demonstrate multiple variably enhancing lesions (often >2) typically located in the juxtacortical white matter, infratentorial space, and spinal cord.
SPIs are clusters of genes on the chromosome, likely to be horizontally acquired, and variably associated with enhanced invasion and intracellular survival within both phagocytic and non-phagocytic cells.
Even if the evidence is limited, hypoechoic hepatic lesions derived from sarcoidosis appear, after UCA injection, as variably arterial enhancing and progressively hypoenhancing nodules in the portal-venous and late phases [ 10, 65].
Less attention has focused on α-ARs, with ex vivo studies or studies in anaesthetised rats variably reporting unchanged [ 16, 21], impaired [ 22, 23] or enhanced [ 24, 25] α-AR activity in the metabolic syndrome.
Bios enhanced.
These 'pseudo-lesions' enhance following Gd DTPA variably throughout the menstrual cycle.
Overall, our results should be helpful to enhance the understanding and modeling of multi-process pesticide transport through structured soils during variably saturated water flow.
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