The code was derived from 21 topological and physicochemical properties of the other two variable substituents.
All inhibitors tested are pyrazolopyrimidine-based compounds with variable substituents at the C3 position.
Low-bandgap poly(2,7-carbazole) derivatives with variable N-substituent of ethyl (PEtCzBT), phenyl (PPhCzBT) and 4-diphenylaminophenyl (PTPACzBT) on the carbazoles, were synthesized through Suzuki coupling reaction.
This plasticity contributes to generate a small hydrophobic pocket for the methyl group typical for RADH substrates, and a hydrophobic coat for the second, more variable and often aromatic, substituent.
The PBDE molecule has two phenol rings linked by an oxygen atom and a variable number of bromine substituents that can bind at 10 different positions.
The synthesis and thermal behaviour of a new series of side-chain liquid-crystalline polyacrylates 1a h containing prochiral alkyl sulfide substituents with a variable number n of carbon atoms are described.
A structure activity relationship within the dataset was established by correlating the effect of aromatic ring substituent constants, structural variables and physico-chemical descriptors with in vivo anti-inflammatory activity.
The developed synthetic route is suitable for the synthesis of focused libraries to enable the structure activity relationship study and late-stage modification of iminosugar scaffold with variable lipid, peptide and sugar substituents.
Two moieties of the 5-HT7/5-HT1A 5-HT7/5-HT1A 5-HT7/5-HT1Anyligandl]-1-(2-methoxyphenyl)piperazine (1) were linked through their 3-methoxy substituent by polymethylene chains of variable length, with the aim to increase the affinity for 5-HT7 receptor and the selectivity over 5-HT1A receptors.
The utility of the polyvinylferrocene derivatives as the positive electrode materials is that their redox potentials are variable with Hammett para-sigma constants of the substituents.
The heme is usually attached to a Cys-X-X-Cys-His (CXXCH) motif in which the X's are variable residues, the Cys residues form thioether bonds to two porphyrin substituents, and the His coordinates the heme iron.
