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With a deeper understanding of the effect polymer size and architecture have on biodistribution, coupled to the development of polymer-protein linkers with differing site-selectivity and variable release rates, the therapeutic potential of cytokines can be significantly enhanced through polymer conjugation.
Importantly, the amount of carbonate scale deposition (scaling progress) is intimately connected with the variable release of CO2 and H2O from the streaming thermal water [see chemical equilibria reported in Eq. (2)].
They acknowledge this had been shown before and point to inaccurate urine collections and variable release of creatinine from muscle as problems [ 2- 4].
In particular, a slower and less variable release rate was observed when the matrix contained the complex (release rate between 0.2 and 0.05 mg/min) (release rate was calculated with the Derivative Macro of Kaleida Graph, Synergy Software (Reading. PA, USA).
DS also allows better homogeneity of the cooling profile throughout the entire sample, whereas, as seen here, PS results in differential thermal profiles towards the sample centre as the excluded solutes, generating areas of local undercooling, result in variable release of latent heat of ice crystal formation which have to be dissipated from the sample core before controlled cooling can proceed.
It was also expected that treatment satisfaction would be greater with insulin glargine given its longer action and constant release of insulin without a pronounced peak, achieved with only one daily injection compared with NPH insulin which even with two injections daily provides variable release of insulin.
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The variable released by NHANES combines these questions and groups people into one of five categories: Mexican American, Other Hispanic, Non-Hispanic Black, Non-Hispanic White, and Other including Multiracial.
Variable INDO release behavior from several matrices was observed suggesting a potential route to tailor drug release based on polymeric excipient use and ratio.
Multiple linear regression was applied to confirm significant effect of each variable on release characteristics.
These includes the ability to fabricate complex geometries to achieve variable drug release kinetics; ease of personalising pharmacotherapy for patient and lowering the cost for fabricating personalised dosages.
Central composite design (CCD) two-factor, five-level was used for the optimization of independent variables AS gum and compression force (CF) based on desired response variable drug release (DR) of paracetamol matrix tablets (PCMT).
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