Mutations in Art underlie human radiosensitive severe combined immunodeficiency (RS-SCID) and SCID-A, primary immunodeficiencies associated with hypersensitivity to DNA-damaging agents and variable lymphoma predisposition [ 5, 9, 10, 16- 18].
This study suggests that the direct correlation of demographic variables with a predisposition to bacterial infection allow the design of an intelligent medical system, which shows great future potential as a powerful diagnostic tool for all physicians.
This study suggests that the direct correlation of demographic variables with a predisposition to bacterial infection allow the design of an intelligent medical system, which shows great future potential as a diagnostic tool for all physicians.
Our study was not designed to answer this question, but we hypothesize that many variables, including genetic predisposition, lifestyle components, and presence of inflammation-related subclinical comorbidities like atherosclerosis or nonalcoholic fatty liver disease, could be relevant contributors.
The reasons are variable and include genetic predisposition, nutrition, and socioeconomic factors.
RASopathies, a family of disorders characterized by cardiac defects, defective growth, facial dysmorphism, variable cognitive deficits and predisposition to certain malignancies, are caused by constitutional dysregulation of RAS signalling predominantly through the RAF/MEK/ERK (MAPK) cascade.
Beckwith-Wiedemann syndrome (BWS), a congenital overgrowth disorder with variable expressivity and a predisposition to tumorigenesis, results from disordered expression and/or function of imprinted genes at chromosome 11p15.5.
Its clinical outcomes in orthodontic patients are highly variable and depend on genetic predisposition, individual biologic variability, and mechanical factors [2].
Our results are not incompatible with those of previous investigations focusing on joint effects of genetic predisposition, assessed in variable ways and selected ConvRFs for CHD.
This defect results in a broad and highly variable clinical phenotype consisting of predisposition to bone marrow failure and malignancy, a triad of mucocutaneous features, and a number of less frequent manifestations such as pulmonary fibrosis and liver disease [ 3].
