Sentence examples for variable periods of ischaemia from inspiring English sources

Previous experimental models of arterial occlusion have confirmed that changes in protein and mRNA expression do occur after variable periods of ischaemia.

After varying periods of ischaemia, sequential changes of the microvasculature occur.

Follicles remain dormant for variable periods of time.

After certain periods of ischaemia, apoptosis may be the predominant pathway to cell death.

Ischaemic preconditioning (IP) describes the process whereby a tissue exposed to brief sublethal periods of ischaemia becomes protected from longer lethal episodes of ischaemia.

Ischaemic preconditioning (IP) involves exposing the heart to brief periods of ischaemia (typically 2 5 min) interspersed with periods of normal perfusion prior to the prolonged ischaemia initiated within an hour of the preconditioning protocol.

The need for longer periods of ischaemia in more metabolically vulnerable patients necessitates further research to improve protection strategies [ 4].

A landmark study by Murry et al. demonstrated that the exposure of the myocardium to short non-lethal ischaemia-reperfusion episodes renders it more tolerant to subsequent severe, potentially lethal, periods of ischaemia, i.e. the heart becomes 'preconditioned'preconditioned

Short periods of ischaemia preserve high-energy phosphate levels and cellular viability in the face of more severe and prolonged ischaemia ('ischaemic preconditioning'), a mechanism in which mitochondrial KATP channels are believed to play a crucial role [ 40].

This is responsible for the production of necrotic regions that are routinely observed after long periods of ischaemia followed by reperfusion.

In order to elucidate the feasibility of using S100A1 calcium-binding protein for monitoring extended periods of ischaemia, we attempted to characterize the ultrastructural localization of S100A1 in the human heart under normal conditions (baseline), after prolonged ischaemia and after reperfusion.