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The small lobe and variable loop are encircled by dotted lines.
The variable loop region was left out since it can not be depicted by this approach.
Thus, we named the loop the variable loop (V-loop) (Figure 1c).
To include also multiple conformations of the variable loop region, the new ensemble docking feature of Gold was used [4].
The publicly available crystal structure lacks a variable loop region that is known to be important for trypanothione biosynthesis.
The residues forming the substrate-binding pocket are located in the small lobe (residue F212) and on or near the variable loop (residues I167, S168, N173, and Q178).
In contrast, substitution of nucleotides in the variable loop adjacent to 48 of the 15:48 base-pair created functional cores.
Homology modeling revealed that the overall structures of B. mori CTL domains are analogous to those of humans with a variable loop region.
This anti-HIV-1 antibody elicited in an infected patient is directed against the third variable loop (V3) of the envelope glycoprotein (gp120) of the virus.
The complex structures of the protein with specific carbohydrates demonstrated the importance of the most variable loop region among homologues for the specificity toward oligosaccharides.
Atragin binds to αvβ3 integrin through a novel interaction mode involving distal M and C domains via the RRN sequence motif in the hyper variable loop.
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