Although information on radiographic OA and site-specific clinical OA was available in two cohorts only, it was included in the harmonized database, as these are main variables in the assessment of OA.
We included nine variables in the Assessment of Different NEoplasias in the adneXa (ADNEX) model: age, serum CA-125 level (log transformed), type of centre, maximum diameter of the lesion (log transformed), proportion of solid tissue (with quadratic term), number of papillary projections, more than 10 cyst locules, acoustic shadows, and ascites.
Barbering should therefore be considered an important variable both in the assessment of the welfare of individual mice and in experiments addressing the impact of husbandry paradigms upon the behavior and welfare of laboratory mice.
Nevertheless, we cannot rule out the possibility that due to (1) incomplete labelling by either the antibody or the lectin, and (2) variable accuracy in the assessment of striosome/matrix borders, we have underestimated the extent of striosomes in our analysis.
Ultrasound, MRI and nuclear medicine techniques, including positron emission tomography (PET), give variable results in the assessment of the axilla.
This methodology complements prior phase 1 analyses of mTOR pathway inhibition used to guide dose selection, and directly links the administered dose of everolimus to change in SLD, a key variable used in the assessment of PFS, the primary end point for the RECORD-1 study.
However, this method has problems arising from the intra-observer and inter-observer variability in the assessment of pathologic variables, which may result in misleading conclusions.
Nonetheless, further studies are needed to confirm these findings and better understand the different variables involved in the assessment of edema using skeletal muscle referencing.
