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It should be noted that in studies using small numbers of patient samples, although genes might be identified that are truly differentially expressed between the samples, the variable expression patterns might be unrelated to the disease state.
We found that conserved Oikopleura notochord genes exhibited variable expression patterns, and some of these genes were expressed in other tissues in addition to the notochord.
Also, in the current study, we analysed the variable expression patterns of the different dystrophin isoforms across brain areas and development stages.
As an example of the kind of meta-analysis that is possible with a large public microarray expression database, we identify genes with very stable expression patterns, suitable as reference or control genes in northern blots, and genes with highly variable expression patterns in 162 Arabidopsis experiments.
We identify 90 candidate genes that have variable expression patterns when comparing two active states (Active 1 and Active 2) with a torpor state.
In primary metabolic pathways where variation may be detrimental, this may actually select against the presence of duplicated genes and variable expression patterns.
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Another HSPC member, Hspc5, exhibits a more variable expression pattern, but is generally highly expressed.
We report that human genes are highly diverse in terms of their EV; while some genes have highly variable expression pattern, some seem to be relatively ubiquitously expressed across a wide range of conditions.
(iii) Furthermore, the variable expression pattern of v-rDNA among different tissues is unlikely the result of promoter exchange via recombination between non-homologues rDNA loci during organogenesis.
In fkhyd2 mutant embryos (which show a very similar expression pattern to hyd1 mutant embryos; not shown), a more variable expression pattern of proAtHB8∶GUS activity is seen, associated with a variable morphology between siblings (Figs. 3C G).
In the remaining cases, a variable expression pattern of the protein was observed.
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