Further, the lack of variable editing across brain tissues and across individuals argues that RNA editing in the brain is critically maintained at an optimal level, supported by observations of dysregulated RNA editing in cancer [ 52].
The Nokia WAP Toolkit provides great error feedback and editing of WML, WMLScript, WBMP image files as well as variable viewing editing and timer status in the running browser.
An example is a recent study investigating variable RNA editing frequencies among a wide sampling of liverworts and mosses in two selected mitochondrial loci.
However, chloroplast RNA editing is highly variable, with more edits in lower taxa of land plants.
It's a command-line tool, and a shortcoming of the installer is that it doesn't add the GnuPG directory to your path, so you should do that now: right click My Computer, click Properties, select Advanced, click the "Environment Variables" button, highlight the PATH variable, click the Edit button, and add at the end something like this: "C:\Program Files (x86)\GNU\GnuPG".
Amino acid sequences were aligned using MAFFT (Katoh and Standley, 2013), highly variable sites were edited by trimAL (Capella-Gutierrez et al., 2009) and after manual inspection.
It is recommended to edit the variable in the box "User variables for (your username)".
Plant mitochondrial RNA editing sites are abundant and highly variable, with approximately 189 635 edits in angiosperms (Bentolila et al. 2013; Grimes et al. 2014; Sloan et al. 2010), whereas plastid RNA edits are relatively limited, with 21 44 nucleotide conversions in seed plants (Chen et al. 2011; Lin et al. 2015a, b; Sasaki et al. 2003, 2006; Tsudzuki et al. 2001; Zeng et al. 2007).
The predicted maps of RNA editing for T. cruzi (Additional File 3) showed that while the final edited mRNA was conserved due to the required amino acid composition of the resulting proteins the gRNAs that perform the editing were variable from one strain to the next; this variability was not restricted to transition mutations.
