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Simultaneously, a theoretical prediction model was formulated in light of variable analyses and a great number of simulations.
All statistical analysis was performed using Anova on multiple variable analyses and Student's t-test on paired analyses.
Table 2 shows the estimated hazard ratios (HRs) for the primary and secondary endpoints for trends in variables that were significant after adjusting for multiple testing in individual variable analyses and after inclusion in multivariate analyses.> -wrap-foot> aConfidenceence interval; GCS, Glasgow Coma Scale; HR, Hazard ratio; ICU, Intensive care unit; SOFA, Sequential Organ Failure Assessment.
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Heterogeneity was assessed using the I2 measure that describes the percentage of total variation in the pooled estimate that is due to between study heterogeneity.[34] Additional information on statistical analyses, including the instrumental variables analyses, and strengths and limitations of this method, are provided in the supplementary material on the journal website (Text S1).
The factors included in the multivariable model were selected from the results of the single-variable analyses, and by application of a backward stepwise selection method using the Akaike information criterion (AIC) to exclude irrelevant factors.
Our study extends these observations by analyzing both aspects of coronary disease within a single cohort, by adjusting for relevant risk factors in multi-variable analyses, and by the use of digital angiography and a fully quantitative method for assessing atherosclerotic burden thereby permitting more accurate measurement.
Therefore, the first trial data was removed for all conditions from subsequent dependent variables analyses and Fitts' law model derivation.
To deliver experiment-sharing capabilities (an "experiment" is defined as a set of connected raw data variables, analyses and their results), the platform implements a team-based sharing mechanism.
BE conceived the study, participated in the study design, approved the protocol and variables analysed, and drafted the manuscript.
Concentrating our attention on postoperative issues, this indicated a strong association between the postoperative variables analysed and the three groups.
A breakdown of the different clinical variables analysed and the differences in these variables across the three study groups is given in Additional file 3: Table S3.
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