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These results indicate that prodrug 2 has the potential for safer, lower, less frequent, and less variable administration than ribavirin.
Using a mix of clinical variables (age and stroke severity), a process variable (administration of thrombolysis) and a biomarker (plasma copeptin), the authors were able to predict 3-month disability.
We drew up calculating tables based on a standard dilution and a variable administration rate controlled by the flow regulating device, thus permitting precise and constant dose administration in millilitres/hour (ml/h).
There were no significant correlations between the SBF ratio and any hemodynamic or blood gas-derived variable, administration of vasoactive drugs (Additional file 1: Figure S4), presence of sepsis (Additional file 1: Table S3), degree/severity of organ dysfunction (SOFA score), initial forearm temperature or the difference between the central to forearm temperature (Additional file 1: Figure S5).
Moreover, this discussion illustrates that small sample size and variable administration strategies - the common criticisms of HTS studies [ 3] - are not compelling.
The exposure variable, administration of dextrose, was defined as any administration of a dextrose bolus without concurrent administration of insulin during the cardiac arrest.
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This is in part due to use of various technologies to measure acid base variables, administration of fluid or medication that can alter acid base results, and lack of standardized nomenclature.
Fig. 5 Sumatriptan had no effect on wheel running in rats not treated with AITC. a Wheel running was variable following administration of sumatriptan (1 mg/kg) or saline (1 mL/kg) in the absence of headache.
The dependent variable was administration of IM therapy during admission.
One should confer this highly variable HEN administration rates in Poland to the prevalence rates of pediatric disorders that usually require enteral nutrition in respective regions.
In this analysis, the dichotomous variable (clonidine administration: yes-no) was a better predictor for the norepinephrine levels than variables including the clonidine dose (absolute dose or dose per body weight), indicating that our data provide no evidence for a strong dose-responsiveness of clonidine in this context.
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