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The final modular design can easily adapt to the route upgrades and changes within the station by simple variable adjustments.
In this prediction process, SPRP employs the actual changes of the low-fidelity model response (or the surface approximation model) due to the design variable adjustments.
To easily accommodate continuous traits and variable adjustments, GMDR is based on scores of a (generalized) linear model.
However, our analyses did not consider the propensity score nor instrumental variable adjustments due to the limited baseline data available from the electronic medical record database and lack of a credible instrumental variable that can be identified in the literature.
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Variable adjustment for confounding and disparate analytic strategies (due to the nature of studies included) means that caution is needed in direct comparisons between studies.
The measure of error and effects is considered to guide the actions to be taken in terms of input variable adjustment.
We dropped individuals with missing information on control variables rather than using the "dummy variable adjustment" method because deletion has been found to produce less-biased estimates (Allison 2001).
Further studies are needed to determine risk prediction ability of this marker, with clearer description of the study population and variable adjustment for simple clinical risk factors, such as age, sex, smoking habits, diabetes, obesity, and lipid panel abnormalities.
More importantly, we found that high ApoA1/HDL-C ratio in serum was significantly associated with diabetes, and was superior to other variables, even after multiple-variable adjustments.
However, these analyses did not involve any multi-variable adjustments, so it is unclear how far this association may be explained by confounding with socio-economic and other factors.
Interestingly, our observations were sensitive to two specific variables – adjustments for QALY after surviving sepsis and the incidence of sepsis due to candidemia.
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