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TDM may be beneficial given this pharmacokinetic variability to avoid treatment failure as well as minimise the emergence of resistance, particularly in the presence of less susceptible pathogens such as Pseudomonas aeruginosa which may have MICs of >0.5 mg/l [ 21, 134, 135].
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Asynchrony was also analyzed using a standardized automated method over the same period, to prevent interobserver variability and to avoid observer subjectivity [19].
Linking health outcomes to these exposures using urinary metabolites requires understanding temporal variability within subjects to avoid exposure misclassification.
The results revealed that the number of exceptionally differentiated 'outlier loci', allele-frequency clines, and the overall distribution of genomic differentiation were recognizably affected by multiple factors such as host-plant use, geographic distance, climatic variability, and selection to avoid maladaptive hybridization (i.e., reinforcement) [ 44].
To avoid variability due to hormonal changes, women were recorded outside their pre-menstrual or menstrual periods.
To avoid variability owing to hormonal changes, female participants underwent MRI outside of their pre-menstrual or menstrual periods.
Prior to quantification, DOR must be deconjugated to avoid variability caused by the polymorphic glucuronosyltransferase enzyme.
We used the width criterion to avoid variability due to manual identification by different people and the change in SOHO/LASCO image cadence in 2010.
On each pre-scan a tight ROI was drawn around the activity columns of the syringe set in a standard manner to avoid variability due to the shape of the ROI.
Negative control staining was performed by omitting the primary antibodies and, in order to avoid variability in the background staining due to the procedure, each treated animal was simultaneously stained with the corresponding control and processed at the same time.
The N-PASS is a strategy to avoid variability of the final result of the Correlation Coefficient (CC) (Song et al. 2011), where the fitness score of a Chromosome is computed as the average of 10 runs.
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