To introduce intra-subpopulation cell-to-cell variability (termed herein noise), for each run of the simulation we sampled the values for the total Raf, Mek and Erk levels from a Normal distribution N around the respective initial concentration for a given set of fractional deviation from the mean (σ= μ· f d, where f d∈{0.1,0.2,0.3,0.4,0.5,0.6,0.7}).
Exponential interpatient variability terms were included for CL/F, V2/F, and Q/F.
The inputted model parameters here include macrokinetic or microkinetic constants, initial conditions of ordinary differential equations (ODEs) and variability terms; MatVPC allows for implementing both interindividual variability and RUV, which can be in the form of proportional, additive, or combined error.
The variability term was a function of the average intensity of the probe set for the 0 hour time point.
For each probe set, the signed area values were averaged over the two replicates and divided by a variability term.
Even more significantly, the model also incorporates terms for explaining the variability of catalyst phase distribution with changes in electrolyte composition in the aqueous phase, which subsequently affects the amount of inorganic nucleophile that reacts in the organic phase.
Estimated population PK parameters, along with variability between subject (BSV) and residual terms for drug and IL-1β, are reported in Table 1.
The ambiguity quantifies how a term can refer to different concepts, while the variability reflects the average number of unique terms for each concept.
The results highlight wide variability in terms of potential impacts for ecosystems and human health.
Variability in terms of genetic divergence for agronomic traits is the key component of breeding programmes for broadening the gene pool of rice and requires reliable estimates of heritability to plan an efficient breeding programme [ 9].
It is likely that there is wide variability in terms of the risk for influenza transmission across the spectrum of outside-the-home activities the students engaged in (i.e., differences in duration and proximity of exposure to other persons).
