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Variability of the product can be reduced by two stages.
Since the process capability index (Cpm) shows the balance of quality responsibility between the design and the manufacturing engineers, this is taken as the basis in developing the functional relationship between the variability of the product and the tolerance.
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Based on the VM, it is possible to select the control loops responsible for the major impact in the variability of the products and which should be the vocation of the loop: good performance of robustness.
The design of the supply chain, and in particular of the distribution phase, for fresh-food products, such as fresh and fresh-cut produce, fruit or meat, cannot be achieved without considering the perishable nature and the variability of the products entering the chain.
The reproducibility of the CPH substrate assays was tested by setting up a series of replicate reactions and measuring the variability of the products (Additional file 2: Figure S2).
The guidance on warfarin recommended a four-way, fully replicated crossover design in order to scale BE limits to the variability of the reference product and compare test and reference product within-subject variability [ 22].
The minimum number of batches that should be tested depends on the variability of the reference product and on the assay variability.
The BE limits would change as a function of within-subject variability of the reference product (reference-scaled average BE).
These varied results may possibly be due to MSC use across wide range of autoimmune disorders with clinical heterogeneity or due to variability of the cellular product.
In particular, we discuss plans produced, respectively, by a two-stage stochastic planning model, by a robust stochastic optimization planning model, and by an equivalent deterministic planning model which integrates the variability of the finished-product demands.
Relatively few on-line measurements and frequent disturbances often result in a significant amount of variability in the product quality variables for this system.
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