However, confidence intervals (CI) are also necessary to fully cover the variability of the point estimates.
The variability of the point estimate across partitions (replicates) reflects uncertainty due to sampling of TRN and TST sets, and a precise estimate of prediction accuracy can be obtained by averaging the estimates of accuracy obtained in each partition.
To obtain estimates of variability for the point estimates, we used the profile likelihood function to calculate 95%% confidence intervals.
Although several cases with similar chromosomal abnormalities have been described, the contribution of specific regions in the development of the characteristics of the syndrome is not clear, due to: 1) the high number of genes implicated, 2) the variability of the break points and 3) the fact that not all of the cases correspond to pure terminal trisomies.
The phantoms were both placed within the focal zone of our imaging system but were not perfectly aligned, in order to test the variability of the estimated point spread function over the focal range.
This process is further complicated by the high variability of the starting point and extent of the transformation process in different individuals [9].
First, the variability of the end point, histological steato-hepatitis, is even greater than for the other features of chronic liver disease, fibrosis and steatosis.
Looking at affected children (in my professional activity) even within the same sibship, with identical mutations, there is often marked intrafamilial variability of the phenotype, pointing to the relevance of genetic modifiers and probable interaction with other cilia-genes.
Because only a single reading of the images was performed in this study, the intra-reader and inter-reader variability of the nine-point MRI cartilage score is not known.
The variability of the 9-point SMPG profile was similar at 1.5 mmol/l with both IDeg and IDet after 26 weeks of treatment [estimated mean treatment ratio (IDeg/IDet): 0.95 (0.85; 1.07)95%CI, p = 0.43].
