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Previous studies examining the variability of substrates utilization at high intensities did not report intensities and total fat and CHO oxidation values when RQ ≥1.
Thus far, pan-eukaryotic classification of kinase substrate sequences has not been attempted and would give better insight in the evolution and variability of substrates and their kinases.
With regard to point (a), little experimental data is available for most kinases with regard to the sequence variability of substrates, structural detail of kinase-substrate complexes, kinetic or energetic aspects of the interaction.
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Recent findings indicate a role for the UGT2B7 expressed in the liver, for variability of substrate effects.
The data, as illustrated in Figure 3B, shows that the variability of substrate combinations with a large efficiency index (C i + ≥ 0.8) increased with the advanced objective function.
Since Colo320 cells are sensitive for 5′DFUR, despite the lack of detectable cleavage of TdR, there is apparently a variability of substrate specificity of UP and TP from the different cell lines.
To determine whether variability of substrate or active γ-secretase complexes could be tolerated for our analysis, Pen-2 KO cells were first transfected with a standard amount (1.5 μg) of wt F-Pen-2 DNA and increasing amounts of C99 DNA.
Interpretation of drug-induced effects on the ECG is however challenging due to the variability of cardiac substrates and also to the frequent multichannel action of most compounds.
Due to the variability of the substrate, bonding to intra-radicular dentin has been considered a challenge and a variety of cements and corresponding adhesive systems may be proposed for bonding fiber posts to root canal dentine.
Polyurethane foam was chosen to minimise the overall variability of bone substrate, as the purpose of this experiment was to compare the stability of different fixation methods.
Such difference may be due to the variability of specific substrate, which can make the biosynthetic pathway different, thus producing different products.
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