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Hence, variability of insulin sensitivity can cause variable glycemia.
Hence, variability of insulin sensitivity can cause variable glycaemia.
Understanding the variability of insulin sensitivity, over hours and days, is important for safely and effectively managing glycemic levels with exogenous insulin.
Variability of insulin sensitivity was calculated as the hour-to-hour percentage change in SI (Δ%SI), defined below: Δ % S I k = 100 × S I k + 1 − S I k S I k (1).
Furthermore, the intraday and day-to-day glycemic variability of insulin glargine was compared with those of insulin detemir.
This study aimed to compare the glucose-lowering effect and glycemic variability of insulin glargine with those of insulin detemir.
Similar(44)
The difference between conventional and close-loop insulin delivery is the ability of the latter to rapidly respond to glucose excursions, with more variability of the insulin infusion rates despite comparable overall insulin doses.
The low glucose-lowering variability of an insulin is desirable, as fluctuations in glucose levels have been shown to increase the risk of retinopathy and neuropathy in patients with Type 1 diabetes and may induce higher rates of hypoglycaemia 31.
This reduced risk for hypoglycemia, as well as a reduction in the need for twice-daily injections, has been attributed to the prolongation of action by retarding subcutaneous absorption, lessening peak activity, and reducing variability of circulating insulin levels.
A major advantage of the Bath protocol may be that relative blood glucose change may give a better indication of the high variability of patients' insulin resistance and the nature and severity of their illness especially in comparison with the Matias protocol.
The VPC shows that the main trend and the variability of glucose and insulin were well captured by the model at all dose levels.
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