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This study presents a new Reliability-based Design Optimization method using adaptive response surface and first-order score function analysis for complex system design optimization considering the variability of design variables.
It is noteworthy that the optimum ductility index is subject to the variability of design, beam geometry, and prestressing level.
The variability of design and architecture of retinal neurons reaches maximum complexity with amacrine cells, which in mammals occur in around 30 different morphological types.
Variability of design specifications within the tolerance field may affect the dynamic behaviour of the assembled structure more than that of any individual component substructure.
However, the spatial variability of design parameters, such as geotechnical and geological properties, greatly affects the behavior of tunnels during and after construction as well as their long-term responses.
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A large variability of designs and approaches has been described [ 11].
Detailed kinetic and inhibition studies using this variant of full-length NS3 can increase the understanding of the enzymatic characteristics of NS3, reveal the importance of the substituted amino acids and the significance of the genetic variability for design of effective inhibitors of the virus, and is thus of relevance for drug discovery.
Besides, the contextual design goal model captures the inherent variability of the design space, through the definition of alternative refinements for the same design element.
Inherent spatial variability (ISV) of design soil properties (e.g., effective friction angle φ′) can be incorporated into probability-based geotechnical analyses and designs using random field models.
The work of (Pimentel et al. 2014) explores the flow expressions in their multi-dimensional approach that exploits inherent variability of the design space.
An important aspect of quantitative risk analysis (QRA) concerns taking into account the variability of the design parameters.
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