Interpretation of results is further complicated by variable routes of administration, concentrations and age variability of research subjects.
According to this population analysis, the developmental effects of BW and age explained a part of the pharmacokinetic and pharmacodynamics between-subject variabilities of Ep administration in critically ill children.
However, they showed that plasma concentrations were higher in case of altered renal function and highlighted the interindividual variability of concentrations after administration of high doses of cloxacillin.
With regard to variability of dosage and administration strategies, Mortazavi and colleagues suggest they are clinically irrelevant [ 6].
This review discusses the pharmacological attempts at treatment optimisation, which include reducing interindividual pharmacokinetic and pharmacodynamic variability, optimising schedule, route of administration, reversing drug resistance and the development of structurally related second-generation taxanes.
Since its clinical introduction, attempts to improve docetaxel treatment have covered various areas: reducing the interindividual pharmacokinetic (PK) and pharmacodynamic (PD) variability, optimising schedule, route of administration and drug formulation, and reversing drug resistance.
However, t max showed less intersubject variability following administration of diluted aspart (SD 14.4 vs 8.7 min, p = 0.047).
During the influenza A(H1N1 pmd09 pandemic, considerable variability in administration of TIV and pandemic vaccines occurred, with some authorities recommending co-administration, and others recommending that TIV be given a month or more after the pandemic vaccine.
Higher missing values for parent proxy-reports may have been due to differences in mode of administration and variability in parental literacy or education levels.
The interindividual variability of adduct levels after administration of oxaliplatin was large, especially in comparison to the pharmacokinetic parameters.
