This was expected, based upon previously published work showing gene-to-gene variability in expression patterns, even within monoallelically expressed gene clusters.
Genes that are highly expressed and that exhibit high variability in expression have a high probability of correlating positively with RT PCR data.
However, P. falciparum offers unique challenges in data analysis due to stochastic variability in expression of some gene products, such as variable erythrocyte surface proteins.
Interindividual variability in expression of these isoforms would cause interindividual differences in drug response, toxicity and cancer susceptibility.
In practice, the sources of background variability in expression data can be divided into three categories: technical, physiological, and sampling.
Such variability in expression might help to identify individuals at risk for developing PTDM.
This variability in expression was observed for all the clonal cell lines tested (data not shown).
In humans, CNVs have been shown to underlie variability in expression [22] and complex traits [23].
This variability in expression of these miRNAs may be related to the heterogeneous clinical course.
Only one of these HSPA genes, Hspa12a, shows significant variability in expression levels across the brain.
We were also interested in determining if within-environment variability in expression explained our robustness data.
