There was considerable variability in benefit, and the mean results show similar performance with all three strategies.
As can be seen in Table 1, there is significant variability in completion benefits between the various outcomes.
Our results indicate important tendencies of health benefit influences: From the day-to-day variability in health benefit influences, we infer that the efficacy of long-term pollution reduction measures could vary greatly in the short term.
Temporal variability in health benefit influences.
Our modeling period represents a single O3 season in 2007, and does not capture inter-annual variability in health benefit influences.
The clinical utility of our findings remains to be investigated, although the variability in StartReact benefit may preclude any inferences at the single subject level.
The dependence of atmospheric pollutant transformation and transport on meteorological conditions causes a great deal of day-to-day variability in health benefit attributions.
Also, the data from the analysis is based on historical numbers, and may not be appropriate for any one particular organization given the variability in health care benefits.
An up-to-date high-quality guideline generally means that potential biases of guideline development have been addressed, and that the recommendations are practicable, reflect the balance between desirable and undesirable effects, incorporate quality of evidence, consider variability in values of benefits, risks, inconveniences, and costs [ 10- 12].
Results: We found significant spatiotemporal variability in estimated health benefit influences of NOx and VOC emission reductions on Canada and U.S. mortality.
There is significant variability in the additional benefit reported between pharmaceutical manufacturers, IQWiG and G-BA, and this becomes apparent in four key areas: ACT selection, subgroup definition, definition of patient-relevant endpoints (mortality, morbidity and HRQoL), and the impact of selected adverse events on benefit assessment.
