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Background: Population exposure assessment methods that capture local-scale pollutant variability are needed for large-scale epidemiological studies and surveillance, policy, and regulatory purposes.
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Existing package insert data and data used for FDA and other regulatory approvals do provide some reproducibility data, but they do not quite provide the longitudinal within-subject variability results that are needed for serial testing interpretation.
In this respect, it was found that ingested water is rapidly detected in plasma and blood cells (within 5 min) and reached a peak at 20 min on average (with large inter-subject variability) but about 75 min are needed for the complete absorption of 300 ml of plain water.
Detailed subsurface characterization data that capture geochemical and hydrogeologic variability, including a flux-based analysis, are needed for successful applications of PRB technology for arsenic remediation.
A more consistent and independent proxy for moisture variability was needed to test the possible role of climate in past typhus outbreaks.
Solar activity is typically represented by the international sunspot number (SSN), but there are many other measures, which are needed for a complete understanding of the solar variability.
Ninety percent of data are needed for inclusion of short-term heart rate variability recordings and 80% of data are needed for inclusion of long-term 24-hour recordings.
Large sample sizes are needed for sublingual immunotherapy (SLIT) trials because of inherent data variability secondary to inconsistent allergen exposure.
Even though the genome replication relies on an error-prone RNA-dependent RNA-polymerasis, CHIKV strains S27 and 05.115 Reunion showed in E1 and E2 a low amino acid variation of 0.68% and 3.3%, respectively, and such a low variability may be needed for an effective replication in two phylogenetically distant hosts [ 116, 122].
Modeling of variability is expected to be needed for both data-rich and -sparse chemicals.
A greater variability of familiarity might thus have been needed for the correlation between visual complexity and familiarity to be significant.
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