Although alternative splicing is a most efficient means of enriching the genetic information stored in a single gene, post-translational modification by glycosylation and glycosaminoglycan (GAG) attachments further modifies the CD44 protein, allowing greater expansion of its variability and functions [ 1- 4].
This is in keeping with the abnormal circadian blood pressure variability and endothelial function being functional markers for an adverse cardiometabolic milieu [ 8, 10].
The genes of the major histocompatibility complex (MHC/MH) have attracted considerable scientific interest due to their exceptional levels of variability and important function as part of the adaptive immune system.
Fibrinogen has recently been associated with impaired myocardial systolic function [ 7] and abnormalities of circadian blood pressure variability and endothelial function in obese participants [ 8].
We hypothesized that indices of blood pressure variability and baroreflex function would differ between CFS patients and controls, indicating a predominance of sympathetic cardiovascular control in the former.
Indices of blood pressure variability and baroreflex function (α-gain) were computed from monovariate and bivariate spectra in the low-frequency (LF) band (0.04 0.15 Hz) and the high frequency (HF) band (0.15 0.50 Hz), using an autoregressive algorithm.
Circadian BP variability and endothelial function, along with subtle abnormalities of pro-inflammatory and glycemic milieu, can be novel measures for recognizing latent CVD risk in otherwise asymptomatic obese and possibly in other populations.
This study investigated the overall hypothesis that subtle changes in normal circadian BP variability and endothelial function are influenced by the progressive visceral adipose tissue expansion, the accompanying alteration of the metabolic milieu (glycemic and systemic pro-inflammatory changes) and the overall vascular response to these metabolic perturbations.
Despite these shortcomings, this investigation documents statistically significant novel findings of a clinical correlation between circadian BP variability and endothelial function abnormalities and systemic proinflammation, prediabetes, prehypertension, elevated cardiac risk ratios, and establishes a foundation for further investigation of the underlying mechanisms.
Even in asymptomatic obese adults, abnormalities in circadian blood pressure variability and endothelial function exhibited unfavorable cardiometabolic profiles such as elevated high-sensitivity C-reactive protein, fibrinogen, fasting serum glucose and cardiac risk ratios (Total Cholesterol:HDL-cholesterol and LDL-cholesterol:HDL-cholesterol ratios) [ 56].
