Sentence examples for var elements from inspiring English sources
Using promoter deletion analyses combined with ectopic insertion of var elements into a euchromatic locus we were able to systematically reconstruct some of the control steps of var gene activation and mutual exclusion.
To identify regulatory var promoter elements we employed a system suitable to analyse promoter activity in stably transfected parasites.
Functional gene expression assays using reporter genes highlighted the central role of two var genetic elements in expression.
A var gene intron element is located downstream of the h dhfr-gfp cassette to account for its role in var gene regulation.
Note that the elements of var(b1 b2) were assumed the same across the genome.
Ignoring the off-diagonal elements of var as before, the diagonals of the inverse of the residual variance after factoring out are which simplifies to give (10) an expression analogous to (5) with n = 1 and h2 =.
In the case of the tub var alleles, the transposable element insertions produce a detrimental phenotype.
The effects of energy storage and other circuit elements on the var compensator capability can also be studied from this model and hence the design of the compensator becomes simple.
This implies that mutually exclusive locus recognition may be mediated by cis-acting regulatory sequence elements located in var gene upstream regions.
Nevertheless, those studies suggest that regulatory elements within each var gene contain all the necessary information for the singular gene choice upon activation.
